One of the alleged contraindications to the use of EDTA is possible renal damage. Three hundred and eighty -three subjects with chronic degenerative disorders were treated with EDTA and supportive multivitamin-trace mineral supplements for approximately 50 days. Overall, the fasting serum creatinine levels declined (P<0.05). Specifically, those with relatively low initial serum, creatinine levels increased; those with relatively high, but generally felt to be within the physiologic range, levels declined; those in the area of approximately 1.0 mg/dl (the supposed ideal in terms of renal clearance) remained unchanged. Hence, it would appear, within the limits of this study, that this therapeutic regimen is not nephrotoxic. There is even a suggestion that this treatment procedure may improve kidney function.
E. W. McDonagh, C. J. Rudolph and E. Cheraskin
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